Endocrine Abstracts

Case history: A 42-year-old female presented to the emergency department with dizziness, vomiting, abdominal pain and thirst. While investigating a 3-month history of lethargy, menstrual irregularity and weight loss, her GP had found a raised TSH, FSH and LH and had prescribed levothyroxine and, 1 week prior to admission, Adcal-D3 supplements. On examination, she was hypotensive and hyperpigmented.Investigations: Na+130 mmol/l (132–144), ...

A decrease in insulin sensitivity (IS) is associated with increasing visceral adiposity. An inverse correlation has been demonstrated between Intramyo-(IMTG) and intrahepatocellular triglyceride (HCTG) concentrations and IS. Patients with AA have reduced IS but IMTG and HCTG content has not been studied.Eight patients with AA (IGF-I >ULN, median 1.83×ULN (range1.16–4.38) ((6 M), median age 39.5 (range 23–66) years, median BMI 30.6(23.5...

The majority of adult GH replaced patients reach target IGF1 levels using established injection devices. However, a small but significant cohort of these patients fail to achieve these intended goals. This can be manifested as either a failure to improve (biochemically or symptomatically) despite escalating GH doses, or large variations in IGF1 measurements despite steady GH dosing.The Easypod® device has a memory chip which allows record...

Background: SAH is a significant cause of morbidity and mortality. Survivors report long term psychological distress, sleep disturbance, libido changes and fatigue. Previous studies describe an increased incidence of hypopituitarism.Hypothesis: Evaluation of psychological symptoms and clinical and radiological features of SAH could predict the incidence of hypopituitarism.Patients and Methods: 102 post-interventional SAH survivors ...

Acromegaly causes impaired insulin sensitivity and reduced fat mass. Using acipimox to block lipolysis, the impact of free fatty acids (FFA) on insulin sensitivity in active acromegaly was investigated. 1H MRS was used to quantify triglyceride (TG) content of liver and muscle.Methods: 6 patients with active acromegaly (AA) (5M, age 59 (34–70), IGF-I (ng/ml) (median (range)) (452 (342–1002)) were studied on 2 visits; (i) baseline (BL)...